Pixel-wise Hoffmann analysis over a manually delineated ROI in a stereotactically-induced mouse GL261 glioblastoma. Upper left: RCE image over a Free-drawing ROI type with the locations of two pixels. Upper right: k
map (min −1) over a Free-drawing ROI type (Hoffmann model). Lower: MR signal courses and fitted Hoffmann model in the two selected pixels.