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Table 1 Annotation concept values and their definitions

From: CoMAGC: a corpus with multi-faceted annotations of gene-cancer relations

Concept Value Definition
CGE increased Expression level of the gene is increased.
decreased Expression level of the gene is decreased.
CCS normal- >normal The cell or tissue remains as normal after the change in the gene’s expression level.
normal- >cancer The cell or tissue acquires cancerous properties as the gene expression level changes; some cancerous properties of the cell or tissue are strengthened as the gene expression level changes.
cancer- >cancer There’s no change in the cancerous properties of the cell or tissue despite the change in the expression level of the gene.
cancer- >normal The cell or tissue loses some cancerous properties as the gene expression level changes; some cancerous properties of the cell or tissue are weakened as the gene expression level changes.
unidentifiable The information about whether or not the gene expression level change accompanies cell or tissue state change is not provided.
IGE up-regulated The initial gene expression level is higher than the expression level of the gene in the normal state.
down-regulated The initial gene expression level is lower than the expression level of the gene in the normal state.
unchanged The initial gene expression level is comparable to the expression level of the gene in the normal state.
unidentifiable The information about the initial gene expression level is not provided.
PT observation Cell or tissue change accompanied by the gene expression level change is reported as observed but the causality between the two is not claimed.
causality The causality between the gene expression level change and the cell or tissue change is claimed.
  1. In the definitions, 'normal’ state of cells or tissues refers to the state in which the cells or tissues show no cancerous properties.