Skip to main content

Table 3 Significant HYPs for mouse high fat diet data set (E-MEXP-1755)

From: Reverse causal reasoning: applying qualitative causal knowledge to the interpretation of high-throughput data

Mechanism

Direction

Correct

Richness

Concordance

Ambiguous

Contra

Possible

Observed

a(SCHEM:“serum insulin”)

1

13

2.1E-04

1.1E-02

0

3

228

16

path(SDIS:“food intake”)

1

16

2.0E-07

2.6E-02

0

6

244

22

p(MGI:Ins2)

1

5

1.3E-03

3.1E-02

0

0

33

5

a(CHEBI:insulin)

1

5

3.6E-03

3.1E-02

0

0

41

5

kin(p(PFM:“Akt Family”))

1

5

8.4E-03

3.1E-02

0

0

50

5

path(SDIS:“lung adenocarcinoma”)

1

8

4.0E-04

5.5E-02

0

2

108

10

tscript(complex(NCM:“AP-1 Complex”))

1

8

1.2E-02

5.5E-02

0

2

172

10

a(CHEBI:androgen)

1

11

8.4E-04

5.9E-02

0

4

233

15

bp(GO:“response to endoplasmic reticulum stress”)

1

6

3.5E-06

6.3E-02

0

1

27

7

bp(GO:“response to oxidative stress”)

−1

4

3.1E-02

6.3E-02

0

0

47

4

tscript(p(MGI:Foxa2))

−1

6

3.6E-02

6.3E-02

0

1

122

7

a(CHEBI:glucocorticoid)

−1

6

8.3E-02

6.3E-02

0

1

148

7

bp(GO:“response to starvation”)

−1

7

4.4E-04

9.0E-02

0

2

90

9

  1. Thirteen HYPs meet both richness and concordance thresholds of p < = 0.1 for data set E-MEXP-1755. Five mechanisms meet more stringent p < 0.05 thresholds (in bold).