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Table 4 Top 20 significant HYPs for TNF data set (GSE2638)

From: Reverse causal reasoning: applying qualitative causal knowledge to the interpretation of high-throughput data

Mechanism

Direction

Correct

Richness

Concordance

Ambiguous

Contra

Possible

Observed

tscript(complex(NCH:“Nfkb Complex”))

1

69

6.2E-25

9.2E-16

2

5

417

76

path(SDIS:“bacterial infection”)

1

34

1.6E-10

1.0E-09

0

1

211

35

bp(GO:“replicative cell aging”)

1

33

3.1E-19

1.1E-07

0

3

121

36

p(PFH:“IFNA Family”)

1

25

4.0E-12

4.0E-07

0

1

105

26

a(CHEBI:lipopolysaccharide)

1

26

1.8E-06

7.6E-06

0

3

225

29

tscript(complex(NCH:“AP-1 Complex”))

1

19

2.1E-04

2.0E-05

0

1

167

20

path(SDIS:“tissue damage”)

1

19

1.2E-03

2.0E-05

0

1

191

20

a(SCHEM:“Dietary Lipid”)

1

14

1.0E-07

6.1E-05

0

0

51

14

a(SCHEM:Allergens)

1

17

4.5E-08

7.2E-05

0

1

80

18

bp(GO:angiogenesis)

1

20

6.7E-09

2.4E-04

0

3

115

23

p(HGNC:AGT)

1

17

4.0E-06

3.6E-04

0

2

117

19

tscript(p(HGNC:TP63))

1

17

1.2E-05

3.6E-04

0

2

126

19

kin(p(PFH:“PRKC Family”))

1

17

4.2E-04

3.6E-04

0

2

163

19

kin(p(PFH:“MAPK p38 Family”))

1

14

6.8E-09

4.9E-04

0

1

49

15

a(SCHEM:“Tetradecanoylphorbol acetate”)

1

16

2.5E-04

6.6E-04

0

2

144

18

bp(GO:“response to hypoxia”)

1

49

7.8E-05

9.1E-04

1

22

943

72

path(SDIS:“Photo-oxidative Stress”)

1

10

3.6E-06

9.8E-04

0

0

34

10

a(CHEBI:“arachidonic acid”)

1

15

2.6E-07

1.2E-03

0

2

80

17

tscript(p(HGNC:MEOX2))

−1

17

8.6E-10

1.3E-03

0

3

79

20

a(SCHEM:“Oxidized Low Density Lipoprotein”)

1

17

1.3E-04

1.3E-03

0

3

161

20

  1. Fifty-eight HYPs met richness and concordance thresholds of p < = 0.1 for data set GSE2638; the top twenty significant HYPs, as ranked by concordance are shown.