Skip to main content

Table 5 Top 20 significant HYPs for the PI3K inhibitor data set (GSE17785)

From: Reverse causal reasoning: applying qualitative causal knowledge to the interpretation of high-throughput data

Mechanism Direction Correct Richness Concordance Ambiguous Contra Possible Observed
a(CHEBI:lapatinib) 1 21 1.5E-03 4.8E-07 0 0 72 21
tscript(p(HGNC:FOXO1)) 1 43 2.2E-05 7.0E-06 0 11 208 54
tscript(p(HGNC:FOXO3)) 1 34 1.6E-10 3.4E-05 0 8 103 42
a(SCHEM:Hydrocortisone) 1 41 2.4E-07 4.1E-05 0 12 177 53
a(CHEBI:estradiol) −1 36 1.4E-03 7.8E-05 0 10 199 46
a(SCHEM:“serum insulin”) −1 46 1.5E-07 8.8E-05 0 16 217 62
kin(p(PFH:“PRKC Family”)) −1 26 3.3E-02 1.5E-03 0 8 166 34
a(CHEBI:“nitric oxide”) −1 29 8.2E-03 1.7E-03 0 10 178 39
path(SDIS:“lung adenocarcinoma”) −1 20 1.3E-02 2.0E-03 0 5 106 25
bp(MESHPP:“Menstrual Cycle”) 1 18 5.2E-03 2.2E-03 0 4 84 22
a(CHEBI:camptothecin) −1 23 3.1E-04 5.3E-03 0 8 111 31
p(HGNC:AGT) −1 23 1.1E-03 5.3E-03 0 8 119 31
tscript(p(HGNC:FOXO4)) 1 7 5.6E-03 7.8E-03 0 0 16 7
tscript(p(HGNC:SP5)) 1 17 3.2E-03 8.5E-03 0 5 81 22
a(CHEBI:androgen) −1 35 8.0E-04 8.8E-03 0 17 226 52
bp(GO:“response to heat”) −1 39 1.2E-05 9.2E-03 0 20 229 59
path(SDIS:“viral infection”) 1 42 3.3E-08 1.2E-02 0 23 223 65
kin(complex(NCH:“p85/p110 PI3Kinase Complex”)) −1 22 2.5E-06 1.5E-02 0 9 89 31
kin(p(PFH:“AKT Family”)) −1 14 7.7E-05 1.5E-02 1 4 51 19
a(CHEBI:haloperidol) −1 6 2.4E-02 1.6E-02 0 0 16 6
  1. Forty-five HYPs met both richness and concordance p < = 0.1 thresholds for data set GSE17785. The top twenty HYPs, as ranked by concordance are shown.