From: An integrated pharmacokinetics ontology and corpus for text mining
No. | Error categories | Error type | Frequency | examples | |
---|---|---|---|---|---|
In vivo | In vitro | ||||
1 | There are multiple drugs in the sentence, and the sentence is long. | FP | 6 | 34 | PMID: 12426514. In 3 subjects with measurable concentrations in the single-dose study, rifampin significantly decreased the mean maximum plasma concentration (C(max)) and area under the plasma concentration-time curve from 0 to 24 h [AUC(0-24)] of praziquantel by 81% (P <.05) and 85% (P <.01), respectively, whereas rifampin significantly decreased the mean C(max) and AUC(0-24) of praziquantel by 74% (P <.05) and 80% (P <.01), respectively, in 5 subjects with measurable concentrations in the multiple-dose study |
FN | 2 | 17 | PMID: 10608481. Erythromycin and ketoconazole showed a clear inhibitory effect on the 3-hydroxylation of lidocaine at 5 microM of lidocaine (IC50 9.9 microM and 13.9 microM, respectively), but did not show a consistent effect at 800 microM of lidocaine (IC50 >250 microM and 75.0 microM, respectively). | ||
2 | There is no direct DDI relationship between two drugs, but the presence of some words, such as dose, increase, and etc. may lead to a false positive prediction | FP | 6 | 14 | PMID: 17192504. A significant fraction of patients to be treated with HMR1766 is expected to be maintained on warfarin |
3 | DDI is presented in an indirect way. | FN | 2 | 19 | PMID: 11994058. In CYP2D6 poor metabolizers, systemic exposure was greater after chlorpheniramine alone than in extensive metabolizers, and administration of quinidine resulted in a slight increase in CLoral. |
4 | Design issue. Some NDDI are inferred due to some adjectives (little, minor, negligible) | FP | 1 | 3 | PMID: 10223772. In contrast,the effect of ranitidine or ebrotidine on CYP3A activity in vivo seems to have little clinical significance. |
5 | Unknown | FP | 5 | 44 | PMID: 10383922. CYP1A2, CYP2A6, and CYP2E1 activities were not significantly inhibited by azelastine and the two metabolites. |
 |  | FN | 6 | 26 | PMID: 10681383. However, the most unusual result was the interaction between testosterone and nifedipine. |