Skip to main content

Table 6 In vivo probe inhibitors/inducers/substrates of CYP enzymes

From: An integrated pharmacokinetics ontology and corpus for text mining

CYP enzymes Inhibitors Inducers Substrates
CYP1A2 Ciprofloxacin, enoxacin, fluvoxamine, Methoxsalen, mexiletine, oral contraceptives, phenylpropanolamine, thiabendazole, vemurafenib, zileuton, acyclovir, allopurinol, caffeine, cimetidine, daidzein, disulfiram, Echinacea, famotidine, norfloxacin, propafenone, propranolol, terbinafine, ticlopidine, verapamil Montelukast, phenytoin, smokers versus non-smokers, moricizine, omeprazole, phenobarbital Alosetron, caffeine, duloxetine, melatonin, ramelteon, tacrine, tizanidine, theophylline, tizanidine
CYP2B6 Clopidogrel, ticlopidine prasugrel Efavirenz, rifampin, nevirapine Bupropion, efavirenz
CYP2C8 Gemfibrozil, fluvoxamine, ketoconazole, trimethoprim Rifampin Repaglinide, Paclitaxel
CYP2C9 Amiodarone, fluconazole, miconazole, oxandrolone, capecitabine, cotrimoxazole, etravirine, fluvastatin, fluvoxamine, metronidazole, sulfinpyrazone, tigecycline, voriconazole, zafirlukast Carbamazepine, rifampin, aprepitant, bosentan, phenobarbital, St. John’s wort Celecoxib, Warfarin, phenytoin
CYP2C19 Fluconazole, fluvoxamine, ticlopidine, esomeprazole, fluoxetine, moclobemide, omeprazole, voriconazole, allicin (garlic derivative), armodafinil, carbamazepine, cimetidine, etravirine, human growth hormone (rhGH), felbamate, ketoconazole, oral contraceptives Rifampin, artemisinin Clobazam, lansoprazole, omeprazole, Smephenytoin, S-mephenytoin
CYP3A Boceprevir, clarithromycin, conivaptan, grapefruit juice, indinavir, itraconazole, Avasimibe, carbamazepine, phenytoin, rifampin, St. John’s wort, bosentan, efavirenz, etravirine, modafinil, nafcillin, amprenavir, aprepitant, armodafinil, clobazamechinacea, pioglitazone, prednisone, rufinamide, vemurafenib Alfentanil, aprepitant, budesonide, buspirone, conivaptan, darifenacin, darunavir, dasatinib, dronedarone, eletriptan, eplerenone, everolimus, felodipine, indinavir, fluticasone, lopinavir, lovastatin, lurasidone, maraviroc, midazolam, nisoldipine, quetiapine, saquinavir, sildenafil, simvastatin, sirolimus, tolvaptan, tipranavir, triazolam, ticagrelor, vardenafil, Alfentanil, astemizole, cisapride, cyclosporine, dihydroergotamine, ergotamine, fentanyl, pimozide, quinidine, sirolimus, tacrolimus, terfenadine
ketoconazole, lopinavir/ritonavir, mibefradil, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, telaprevir, telithromycin, voriconazole, amprenavir, aprepitant, atazanavir, ciprofloxacin, crizotinib, darunavir/ritonavir, diltiazem, erythromycin, fluconazole, fosamprenavir, grapefruit juice, imatinib, verapamil, alprazolam, amiodarone, amlodipine, atorvastatin, bicalutamide, cilostazol, cimetidine, cyclosporine, fluoxetine, fluvoxamine, ginkgo, goldenseal, isoniazid, lapatinib, nilotinib, oral contraceptives, pazopanib, ranitidine, ranolazine, tipranavir/ritonavir, ticagrelor, zileuton
CYP2D6 Bupropion, fluoxetine, paroxetine, quinidine, cinacalcet, duloxetine, terbinafine, NA Atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, tolterodine, venlafaxine, Thioridazine, pimozide
  amiodarone, celecoxib, clobazam, cimetidine, desvenlafaxine, diltiazem, diphenhydramine, echinacea, escitalopram, febuxostat, gefitinib, hydralazine, hydroxychloroquine, imatinib, methadone, oral contraceptives, pazopanib, propafenone, ranitidine, ritonavir, sertraline, telithromycin, verapamil, vemurafenib