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Figure 4 | BMC Bioinformatics

Figure 4

From: The causal effect of red blood cell folate on genome-wide methylation in cord blood: a Mendelian randomization approach

Figure 4

Sensitivity of instrumental variable effect estimate (green) and ordinary least squares estimate (blue) to modest ( α c =β c = 0.1) and moderate ( α c =β c = 0.2) unmeasured confounding based on 10,000 simulations. The red bars indicate the original TSLS estimates for the 7 significant loci modeled as the true causal effect in each simulation; the green and blue bars indicate the median instrumental variable and ordinary least squares effect estimates in the presence of unmeasured confounding. The error bars designate the 25th and 75th percentiles of these estimates.

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