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Table 2 Biological process Gene Ontology (GO) enrichment among the 7 GO annotated genes in closest proximity to the loci significantly associated with RBC folate-level

From: The causal effect of red blood cell folate on genome-wide methylation in cord blood: a Mendelian randomization approach

Gene ontology term

Number in significant subset

Number in all GO annotated genes analyzed

Odds ratio

Regulation of dephosphorylation

1

16

133.373

Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

1

19

111.111

mRNA export from nucleus

1

21

99.980

Telomere maintenance

1

24

86.913

mRNA catabolic process

1

29

71.357

Nuclear export

1

45

45.336

Humoral immune response

1

67

30.158

RNA transport

1

67

30.158

RNA localization

1

69

29.265

Nucleobase, nucleoside, nucleotide and nucleic acid transport

1

79

25.487

G-protein coupled receptor protein signaling pathway

2

534

8.915

Homeostatic process

2

555

8.558

  1. Significant over-representation of GO terms among these 7 genes relative to the 10,024 GO annotated genes included in the original analysis was assessed using a Hypergeometric distribution (p < 0.05).