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Table 2 Biological process Gene Ontology (GO) enrichment among the 7 GO annotated genes in closest proximity to the loci significantly associated with RBC folate-level

From: The causal effect of red blood cell folate on genome-wide methylation in cord blood: a Mendelian randomization approach

Gene ontology term Number in significant subset Number in all GO annotated genes analyzed Odds ratio
Regulation of dephosphorylation 1 16 133.373
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 1 19 111.111
mRNA export from nucleus 1 21 99.980
Telomere maintenance 1 24 86.913
mRNA catabolic process 1 29 71.357
Nuclear export 1 45 45.336
Humoral immune response 1 67 30.158
RNA transport 1 67 30.158
RNA localization 1 69 29.265
Nucleobase, nucleoside, nucleotide and nucleic acid transport 1 79 25.487
G-protein coupled receptor protein signaling pathway 2 534 8.915
Homeostatic process 2 555 8.558
  1. Significant over-representation of GO terms among these 7 genes relative to the 10,024 GO annotated genes included in the original analysis was assessed using a Hypergeometric distribution (p < 0.05).