Evolutionary rate differences of four Enterobacteriaceae species. Evaluation of evolutionary rate differences between three sets of genes of interest: ALL -all genes, ESS - essential genes and ADT - approved drug targets). Evolutionary rate was estimated using (pN/pS ratio). In this case pN/pS values were compared using Mann-Whitney U test (wilcox.test in R language, two sided hypothesis tested). Box plots of means of pN/pS with 95% confidence intervals are presented (number of genes in given set are shown in brackets). Result for four species from Enterobacteriaceae. Abbreviations: ECO: Escherichia coli, STM - Salmonella typhimurium, PAU - Pseudomonas aeruginosa, FTN - Francisella novicida.