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Table 1 Summary of the data used at pN/pS analysis

From: The evolutionary rate of antibacterial drug targets

Reference genome (strain with experimental data on essential genes; NCBI Taxonomy ID in brackets) Other strains with complete pairwise alignments with reference genome (NCBI Taxonomy IDs) The number of all genes* The number of essential genes* The number of drug targets*
Escherichia coli K12 ( 83333) 155864, 199310, 316407, 331111, 331112, 362663, 364106, 386585, 405955 4294 771 41
(3104) (616) (31)
Francisella novicida U112 (401614) 119857, 177416, 393011, 393115, 418136, 458234 1719 391 34
(1065) (320) (32)
Haemophilus influenzae Rd KW20 (71421) 262727, 262728, 281310, 374927, 374928, 374930, 374931, 374932, 374933, 375063, 375177, 375432 1581 477 39
(1024) (399) (34)
Helicobacter pylori 26695 ( 85962) 357544, 85963 1576 336 30
(992) (292) (28)
Pseudomonas aeruginosa UCBPP-PA14 ( 208963) 208963, 381754 5892 335 40
(4530) (305) (36)
Salmonella typhimurium LT2 ( 99287) 209261, 220341, 295319, 321314 4425 481 41
(3140) (403) (31)
Staphylococcus aureus N315 ( 93061) 158878, 158879, 196620, 273036, 282458, 282459, 359786, 359787, 367830, 418127, 426430, 93062 2892 351 35
(1918) (277) (28)
Streptococcus pneumoniae TIGR4 ( 170187) 171101, 373153, 406556, 406557, 406558, 406559, 406560, 406561, 406562, 406563 1965 195 37
   (1532) (175) (33)
  1. *All genes, essential genes and drug targets comprised the three groups of genes compared in our study. The final analysis was restricted to genes for which no recombination events were detected, numbers of which are presented in brackets.