The evolutionary rate of antibacterial drug targets

BMC Bioinformatics

Table 3 GO analysis for slowly evolving genes

GO	P-value	Study-fraction	Population-fraction	Description
GO:0005198	2.7e-37	0.00523	0.0359	structural molecule activity
GO:0005515	1.8e-12	0.0257	0.0685	protein binding
GO:0005488	2.9e-12	0.274	0.373	binding
GO:0019843	1.4e-06	0.0028	0.0194	rRNA binding
GO:0015453	0.00043	0.000997	0.00627	oxidoreduction-driven active transmembrane transporter activity
GO:0000104	0.0076	0.000436	0.00285	succinate dehydrogenase activity
GO:0016667	0.011	0.00567	0.012	oxidoreductase activity, acting on a sulfur group of donors
GO:0003735	0.014	0.00392	0.0308	structural constituent of ribosome
GO:0015078	0.027	0.00361	0.00856	hydrogen ion transmembrane transporter activity
GO:0046872	0.045	0.0756	0.105	metal ion binding

Enrichment of GO terms (molecular function domain): data for slowly evolving genes. Ten percent of genes (of eight studied species) with the lowest pN/pS rank comprised the study set. Genes with reliable pN/pS (of eight studied species) comprised the population set. Analysis was performed using Ontologizer (with Benjamini-Hochberg correction for multiple testing and Parent-child-Union Settings).

ISSN: 1471-2105