Figure 6

Receiver-operator-characteristics for the detection of differential expression based on p-values computed with edgeR’s exactTest. The Area-under-the-curve (AUC) depends on the type of preprocessing. Highest AUC is achieved with RSEM counts reported by RSEM. Other methods score slightly lower with htseq-based counts reaching a plateau that is below 1.0 due to the fact that htseq would not report counts for overlapping gene symbols.