Identification of reproducible gene expression signatures in lung adenocarcinoma

BMC Bioinformatics

Table 1 Predictive performances of 16 pathways

Pathway	Database	Number of genes^a	p-value^b	Count^c	Count^d
Apoptosis reactome	Reactome	43	7.58E-06	36	50
Polo-like kinase signaling events in the cell cycle	PID	42	5.86E-05	34	73
Apoptotic execution phase	Reactome	16	1.16E-05	27	48
Intrinsic pathway for apoptosis	Reactome	9	2.22E-06	26	47
Apoptosis KEGG	KEGG	16	6.50E-06	24	31
Biocarta cell cycle pathway	BioCarta	7	2.53E-08	23	47
Cell cycle	KEGG	46	1.64E-04	21	67
APC C-mediated degradation of cell cycle proteins	Reactome	32	3.27E-05	16	57
Regulation of mitotic cell cycle	Reactome	32	3.27E-05	16	57
Cell cycle mitotic	Reactome	60	3.63E-04	12	72
Caspase cascade in apoptosis	PID	9	4.82E-04	12	32
NRAGE signals death through JNK	Reactome	7	1.32E-05	7	25
Cell death signalling via NRAGE NRIF and NADE	Reactome	8	1.53E-04	4	15
Biocarta death pathway	BioCarta	9	5.82E-04	4	19
Apoptotic cleavage of cellular proteins	Reactome	12	4.06E-05	3	17
Regulation of apoptosis	Reactome	18	2.01E-05	1	9

^aOnly genes showing association with survival (P < 0.1) were analyzed.
^bEstimated by using log-rank tests.
^cThe frequency showing p-values < 0.002083 in the 100 trials of the internal validation assessment.
^dThe frequency showing p-values < 0.05 in the 100 trials of the internal validation assessment.

ISSN: 1471-2105