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Table 1 Predictive performances of 16 pathways

From: Identification of reproducible gene expression signatures in lung adenocarcinoma

Pathway Database Number of genesa p-valueb Countc Countd
Apoptosis reactome Reactome 43 7.58E-06 36 50
Polo-like kinase signaling events in the cell cycle PID 42 5.86E-05 34 73
Apoptotic execution phase Reactome 16 1.16E-05 27 48
Intrinsic pathway for apoptosis Reactome 9 2.22E-06 26 47
Apoptosis KEGG KEGG 16 6.50E-06 24 31
Biocarta cell cycle pathway BioCarta 7 2.53E-08 23 47
Cell cycle KEGG 46 1.64E-04 21 67
APC C-mediated degradation of cell cycle proteins Reactome 32 3.27E-05 16 57
Regulation of mitotic cell cycle Reactome 32 3.27E-05 16 57
Cell cycle mitotic Reactome 60 3.63E-04 12 72
Caspase cascade in apoptosis PID 9 4.82E-04 12 32
NRAGE signals death through JNK Reactome 7 1.32E-05 7 25
Cell death signalling via NRAGE NRIF and NADE Reactome 8 1.53E-04 4 15
Biocarta death pathway BioCarta 9 5.82E-04 4 19
Apoptotic cleavage of cellular proteins Reactome 12 4.06E-05 3 17
Regulation of apoptosis Reactome 18 2.01E-05 1 9
  1. aOnly genes showing association with survival (P < 0.1) were analyzed.
  2. bEstimated by using log-rank tests.
  3. cThe frequency showing p-values < 0.002083 in the 100 trials of the internal validation assessment.
  4. dThe frequency showing p-values < 0.05 in the 100 trials of the internal validation assessment.