Figure 1

Simulated time courses of species in the crosstalk model with continuous exposure to IFN-gamma (0.1 nM) or IL-6 (0.1 nM). (A) IFN-gamma stimulation induced much stronger activation of STAT1 than STAT3. (B) IL-6 simulation induced much stronger activation of STAT3 than STAT1. (C) In a balanced competition model, IFN-gamma stimulation induced similar activation of STAT1 and STAT3. (D) In a balanced competition model, IL-6 stimulation induced similar activation of STAT1 and STAT3. (E) With no formation of STAT1/3 heterodimers, IFN-gamma stimulation induced more STAT1 and STAT3 homodimer formation than normal conditions. (F) With no formation of STAT1/3 heterodimers, IL-6 stimulation induced higher STAT1 and STAT3 homodimer formation than normal conditions. In the Figure, SHP2 represents the monomers of inactive SHP2, which did not combine with other molecules or complexes.