Figure 4
From: Elucidating the crosstalk mechanism between IFN-gamma and IL-6 via mathematical modelling
Simulated time courses of species in the crosstalk model after combined stimulation with IFN-gamma and IL-6. (A) Combined stimulation with IFN-gamma and IL-6 induced higher activation of STAT1 and STAT3 than separate treatments. (B) A setting where STAT1 could only be activated by IFN-gamma and STAT3 could only be activated by IL-6 did not abolish the higher activation of STAT1 and STAT3 compared with individual stimulation experiment. (C) Combined stimulation with IFN-gamma and IL-6 reduced the level of PP1 compared with individual treatments. (D) Combined stimulation with IFN-gamma and IL-6 reduced the level of PP2 compared with the individual treatments. (E) Without the formation of STAT1/3 heterodimers, combined stimulation with IFN-gamma and IL-6 did not induce higher levels of (STAT1N*)2 and (STAT3N*) compared with normal conditions.