Figure 6

Simulated time courses of species in the non-competitive model with continuous exposure to IFNγ (0.1 nM) or IL-6 (0.1 nM). (A) IFNγ stimulation induced much stronger activation of STAT1 than STAT3. (B) IL-6 simulation induced much stronger activation of STAT3 than STAT1. (C) With balanced kinetic affinities, IFNγ stimulation induced similar activation of STAT1 and STAT3. (D) With balanced kinetic affinities, IL-6 stimulation induced similar activation of STAT1 and STAT3. (E) STAT1 was phosphorylated more strongly and for longer with a higher level of STAT3 after IFNγ simulation. (F) STAT3 was phosphorylated more strongly and for longer with a higher level of STAT1 after IL-6 simulation.