Figure 8

Sensitivity analysis of the non-competitive model. (A, B) indicate the sensitivities of the initial molecule concentrations and the reaction rate constants after IFN-gamma stimulation. (C, D) indicate the sensitivities of the initial molecule concentrations and the reaction rate constants after IL-6 simulation, respectively. The definition of the parameter sensitivity can refer to the “Methods” section. The positive (or negative) sensitivity values indicate consistent (or opposite) percentage changes in output to the perturbation in the parameter compared to the nominal solution. The red and blue bars represent positive and negative sensitivity values, respectively. For brevity, we only show the top 20 parameters with high sensitivity values.