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Table 6 SVM-based prediction performances (at the default threshold) of PSSM approach on the different independent datasets

From: Prediction of vitamin interacting residues in a vitamin binding protein using evolutionary information

S.No.

Prediction

Dataset

Threshold

Sensitivity

Specificity

Accuracy

MCC

1

VIRs

V-IND-46

−0.8

73.70

71.98

72.07

0.22

−0.1

41.74

96.63

93.72

0.38

2

VAIRs

VA-IND-15

−0.8

73.48

72.87

72.93

0.31

0.0

30.39

97.22

89.77

0.37

3

VBIRs

VB-IND-27

−0.8

83.05

68.76

69.40

0.23

0.1

49.40

94.49

92.47

0.35

4

PLPIRs

PLP-IND-16

−0.7

84.15

83.22

83.26

0.33

   

−0.1

65.85

98.40

97.10

0.63

  1. *Bold value indicates performance at the optimized threshold level of balanced sensitivity and specificity.
  2. **Italic value indicates performance at the optimized threshold level of highest MCC.
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BMC Bioinformatics

ISSN: 1471-2105

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