Disease groups and their significant overlaps. Cytoscape is used to visualize the disease groups and their overlaps. Additional file5 can be directly loaded into Cytoscape to replicate the figure and explore the disease groups. Each node represents a group of related diseases associated with two to 59 genes. Edges represent one or more genes that are shared between disease groups where the width of the edge is proportional to the Jaccard index. The graph is sparse. Only 837 edges exist between the 497 multigenic disease groups and 130 of these overlaps are significant (hypergeometric test, p-value < 0.01 after FDR adjustment) - the above shows only these significant overlaps but all are available in the provided file. A number of connected components group together related disease groups such as cancer and eye disorders (red box magnified in inset).