Figure 3

Disease group overlaps with complexes. Cytoscape is used to visualize disease groups and their overlaps with n-ary interaction records. Additional file7 can be directly loaded into Cytoscape to replicate the figure and explore the overlaps. Disease groups (circular nodes) and n-ary records (hexagonal nodes) that have significant overlaps are indicated by edges whose width is proportional to the jacaard index[31] for the overlap. All disease-group overlaps with complexes are provided in the additional file. Here, significant overlaps (hypergeometric test, p-value < 0.0025 after FDR adjustment) are shown on the right and involve 105 disease groups. The region inside the red box shows an overlap between the Cornelia de Lange syndrome disease group and n-ary records that contain subunits of the cohesion complex. The region inside the green box (and magnified in the left inset) shows two disease groups (Benign familial hematuria and Alport syndrome) that both overlap with the same n-ary record (see text for details).