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Table 2 DiGs related only to regenerated complexes

From: A survey of protein interaction data and multigenic inherited disorders

DiG ID

DiG name

# Genes

Best match (database.pmid.exp_method.icrogid)

Complex span

# significant p-values (raw)

# significant p-values (FDR)

63

alagille syndrome

2

MI:0463(grid).pubmed:10958687.MI:0004(affinity chromatography technology).1144108.MI:0463(grid).pubmed:10958687.MI:0096(pull down).1144108

4

4

1

190

Brachydactyly

7

MI:0463(grid).pubmed:9525338.MI:0096(pull down).248458

13

12

1

246

central hypoventilation syndrome

6

MI:0463(grid).pubmed:10829012.MI:0096(pull down).4168707

13

12

1

271

Chondrodysplasia

6

MI:0463(grid).pubmed:9525338.MI:0096(pull down).248458

13

13

1

290

cockayne syndrome

2

MI:0463(grid).pubmed:10944529.MI:0004(affinity chromatography technology).660979

11

11

2

363

Deafness

59

MI:0463(grid).pubmed:12485990.MI:0096(pull down).1981308

134

56

1

424

endometrial carcinoma

5

MI:0463(grid).pubmed:8942985.MI:0096(pull down).813561.MI:0463(grid).pubmed:10029069.MI:0096(pull down).813561.MI:0463(grid).pubmed:9774676.MI:0096(pull down).813561.MI:0469(intact).pubmed:9774676.MI:0096(pull down).813561

105

103

5

451

Exostoses

2

MI:0463(grid).pubmed:17353931.MI:0004(affinity chromatography technology).3748087.MI:0469(intact).pubmed:17353931.MI:0006(anti bait coip).3748087

13

13

1

512

gastric cancer

11

MI:0469(intact).pubmed:19411071.MI:0006(anti bait coip).3231405

194

190

2

687

Ichthyosis

13

MI:0469(intact).pubmed:17373842.MI:0006(anti bait coip).1386965

25

21

1

714

jackson-weiss syndrome

2

MI:0463(grid).pubmed:20388777.MI:0004(affinity chromatography technology).3027803

16

16

1

730

Keratosis

6

MI:0463(grid).pubmed:11790773.MI:0004(affinity chromatography technology).2791010

65

60

5

772

liddle syndrome

2

MI:0463(grid).pubmed:14996668.MI:0004(affinity chromatography technology).382851

14

14

8

829

medullary thyroid carcinoma

2

MI:0463(grid).pubmed:8183561.MI:0004(affinity chromatography technology).1871880

26

26

1

904

Mycobacterium

10

MI:0463(grid).pubmed:10848598.MI:0004(affinity chromatography technology).1004542

45

42

2

933

nephrotic syndrome

4

MI:0463(grid).pubmed:11733557.MI:0004(affinity chromatography technology).3453124.MI:0463(grid).pubmed:11733557.MI:0096(pull down).3453124

8

8

1

959

noonan-like/multiple giant cell lesion syndrome

2

MI:0463(grid).pubmed:9344843.MI:0004(affinity chromatography technology).5369795

100

100

1

999

Osteosarcoma

2

MI:0463(grid).pubmed:12242661.MI:0004(affinity chromatography technology).3633225

340

340

318

1049

pfeiffer syndrome

2

MI:0463(grid).pubmed:20388777.MI:0004(affinity chromatography technology).3027803

16

16

1

1051

pheochromocytoma

6

MI:0463(grid).pubmed:10829012.MI:0096(pull down).4168707

115

109

1

1071

pituitary hormone

5

MI:0463(grid).pubmed:10788441.MI:0096(pull down).3747010

9

9

1

1165

rhabdomyosarcoma

4

MI:0463(grid).pubmed:17662948.MI:0004(affinity chromatography technology).2068280

30

30

1

1233

Sitosterolemia

2

MI:0471(mint).pubmed:16870176.MI:0007(anti tag coip).3242301

2

2

1

1260

squamous cell carcinoma

3

MI:0463(grid).pubmed:15659383.MI:0401(biochemical).4258047

52

52

12

1574

Tuberculosis

3

MI:0463(grid).pubmed:7673114.MI:0096(pull down).4202157

9

9

1

  1. Summary of the 25 DiGs that are significantly similar to protein complexes but can only be found in iRefIndex regenerated complex data: Ichthyosis (DiG ID = 687) is a DiG that groups 13 genes. At least one of the 13 genes in this DiG was present in 25 complexes present in iRefIndex regenerated n-ary data (complex span = 25) but only 21 of them could be considered as significantly similar after a hypergeometric test with a p-value < 0.05. After adjusting the p-values for multiple testing using the FDR method, only 1 of those complexes could be considered significantly similar to the DiG.