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Table 2 DiGs related only to regenerated complexes

From: A survey of protein interaction data and multigenic inherited disorders

DiG ID DiG name # Genes Best match (database.pmid.exp_method.icrogid) Complex span # significant p-values (raw) # significant p-values (FDR)
63 alagille syndrome 2 MI:0463(grid).pubmed:10958687.MI:0004(affinity chromatography technology).1144108.MI:0463(grid).pubmed:10958687.MI:0096(pull down).1144108 4 4 1
190 Brachydactyly 7 MI:0463(grid).pubmed:9525338.MI:0096(pull down).248458 13 12 1
246 central hypoventilation syndrome 6 MI:0463(grid).pubmed:10829012.MI:0096(pull down).4168707 13 12 1
271 Chondrodysplasia 6 MI:0463(grid).pubmed:9525338.MI:0096(pull down).248458 13 13 1
290 cockayne syndrome 2 MI:0463(grid).pubmed:10944529.MI:0004(affinity chromatography technology).660979 11 11 2
363 Deafness 59 MI:0463(grid).pubmed:12485990.MI:0096(pull down).1981308 134 56 1
424 endometrial carcinoma 5 MI:0463(grid).pubmed:8942985.MI:0096(pull down).813561.MI:0463(grid).pubmed:10029069.MI:0096(pull down).813561.MI:0463(grid).pubmed:9774676.MI:0096(pull down).813561.MI:0469(intact).pubmed:9774676.MI:0096(pull down).813561 105 103 5
451 Exostoses 2 MI:0463(grid).pubmed:17353931.MI:0004(affinity chromatography technology).3748087.MI:0469(intact).pubmed:17353931.MI:0006(anti bait coip).3748087 13 13 1
512 gastric cancer 11 MI:0469(intact).pubmed:19411071.MI:0006(anti bait coip).3231405 194 190 2
687 Ichthyosis 13 MI:0469(intact).pubmed:17373842.MI:0006(anti bait coip).1386965 25 21 1
714 jackson-weiss syndrome 2 MI:0463(grid).pubmed:20388777.MI:0004(affinity chromatography technology).3027803 16 16 1
730 Keratosis 6 MI:0463(grid).pubmed:11790773.MI:0004(affinity chromatography technology).2791010 65 60 5
772 liddle syndrome 2 MI:0463(grid).pubmed:14996668.MI:0004(affinity chromatography technology).382851 14 14 8
829 medullary thyroid carcinoma 2 MI:0463(grid).pubmed:8183561.MI:0004(affinity chromatography technology).1871880 26 26 1
904 Mycobacterium 10 MI:0463(grid).pubmed:10848598.MI:0004(affinity chromatography technology).1004542 45 42 2
933 nephrotic syndrome 4 MI:0463(grid).pubmed:11733557.MI:0004(affinity chromatography technology).3453124.MI:0463(grid).pubmed:11733557.MI:0096(pull down).3453124 8 8 1
959 noonan-like/multiple giant cell lesion syndrome 2 MI:0463(grid).pubmed:9344843.MI:0004(affinity chromatography technology).5369795 100 100 1
999 Osteosarcoma 2 MI:0463(grid).pubmed:12242661.MI:0004(affinity chromatography technology).3633225 340 340 318
1049 pfeiffer syndrome 2 MI:0463(grid).pubmed:20388777.MI:0004(affinity chromatography technology).3027803 16 16 1
1051 pheochromocytoma 6 MI:0463(grid).pubmed:10829012.MI:0096(pull down).4168707 115 109 1
1071 pituitary hormone 5 MI:0463(grid).pubmed:10788441.MI:0096(pull down).3747010 9 9 1
1165 rhabdomyosarcoma 4 MI:0463(grid).pubmed:17662948.MI:0004(affinity chromatography technology).2068280 30 30 1
1233 Sitosterolemia 2 MI:0471(mint).pubmed:16870176.MI:0007(anti tag coip).3242301 2 2 1
1260 squamous cell carcinoma 3 MI:0463(grid).pubmed:15659383.MI:0401(biochemical).4258047 52 52 12
1574 Tuberculosis 3 MI:0463(grid).pubmed:7673114.MI:0096(pull down).4202157 9 9 1
  1. Summary of the 25 DiGs that are significantly similar to protein complexes but can only be found in iRefIndex regenerated complex data: Ichthyosis (DiG ID = 687) is a DiG that groups 13 genes. At least one of the 13 genes in this DiG was present in 25 complexes present in iRefIndex regenerated n-ary data (complex span = 25) but only 21 of them could be considered as significantly similar after a hypergeometric test with a p-value < 0.05. After adjusting the p-values for multiple testing using the FDR method, only 1 of those complexes could be considered significantly similar to the DiG.