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Table 3 DiGs enriched only in binary interactions

From: A survey of protein interaction data and multigenic inherited disorders

DiG ID DiG name # Genes # binary interactions in DiG p-value
156 basal cell carcinoma 4 2 1.1e-05
263 charcot-marie-tooth disease 26 4 2.0e-4
305 Immunodeficiency 12 4 3.8e-07
310 retinal dystrophy 22 4 5.4e-05
379 diabetes mellitus 44 12 7.7e-11
538 Glutaricaciduria 4 3 1.3e-08
542 glycine encephalopathy 3 3 6.3e-10
543 glycogen storage disease 19 6 1.1e-08
581 Hemochromatosis 5 2 3.3e-05
626 Hypercholesterolemia 9 3 4.4e-06
628 Hyperekplexia 5 2 3.3e-05
644 Hyperphenylalaninemia 4 2 1.1e-05
780 Lissencephaly 5 2 3.3e-05
850 Methemoglobinemia 4 2 1.1e-05
996 Osteopetrosis 8 2 2.7e-4
1081 polycystic kidney 4 2 1.1e-05
1092 Porphyria 6 5 1.4e-12
1153 retinitis pigmentosa 43 8 1.6e-06
1300 Thrombocythemia 3 2 2.2e-06
1536 myocardial infarction 13 4 7.4e-07
  1. Summary of the 20 DiGs that are enriched in iRefIndex binary interactions and can only be found using this method: Glycine encephalopathy (DiG ID = 542) is a DiG that groups 3 genes. There are 3 possible interactions between 3 genes. Finding all of them in the PIN is a very unlikely event (hypergeometric p-value close to zero) and, therefore, the existence of a functional group of proteins related to the disease can be hypothesized.
  2. “immunodeficiency” stands for immunodeficiencies due to defects in CD3, MAPBP-interacting protein, with hyper IgM and X-linked.