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Table 3 DiGs enriched only in binary interactions

From: A survey of protein interaction data and multigenic inherited disorders

DiG ID

DiG name

# Genes

# binary interactions in DiG

p-value

156

basal cell carcinoma

4

2

1.1e-05

263

charcot-marie-tooth disease

26

4

2.0e-4

305

Immunodeficiency

12

4

3.8e-07

310

retinal dystrophy

22

4

5.4e-05

379

diabetes mellitus

44

12

7.7e-11

538

Glutaricaciduria

4

3

1.3e-08

542

glycine encephalopathy

3

3

6.3e-10

543

glycogen storage disease

19

6

1.1e-08

581

Hemochromatosis

5

2

3.3e-05

626

Hypercholesterolemia

9

3

4.4e-06

628

Hyperekplexia

5

2

3.3e-05

644

Hyperphenylalaninemia

4

2

1.1e-05

780

Lissencephaly

5

2

3.3e-05

850

Methemoglobinemia

4

2

1.1e-05

996

Osteopetrosis

8

2

2.7e-4

1081

polycystic kidney

4

2

1.1e-05

1092

Porphyria

6

5

1.4e-12

1153

retinitis pigmentosa

43

8

1.6e-06

1300

Thrombocythemia

3

2

2.2e-06

1536

myocardial infarction

13

4

7.4e-07

  1. Summary of the 20 DiGs that are enriched in iRefIndex binary interactions and can only be found using this method: Glycine encephalopathy (DiG ID = 542) is a DiG that groups 3 genes. There are 3 possible interactions between 3 genes. Finding all of them in the PIN is a very unlikely event (hypergeometric p-value close to zero) and, therefore, the existence of a functional group of proteins related to the disease can be hypothesized.
  2. “immunodeficiency” stands for immunodeficiencies due to defects in CD3, MAPBP-interacting protein, with hyper IgM and X-linked.