Estimation of CpG coverage in whole methylome next-generation sequencing studies

BMC Bioinformatics

Table 3 Comparison of coverage estimates obtained using different methods

	Mean	SD	Ratio	Correlation
Paired-end	6.168	3.282	100.0%	1.000
Read count (50 bp)	1.824	1.357	29.6%	0.608
Read count extended (150 bp)	5.385	3.036	87.3%	0.934
Individual kernel function	6.207	3.287	100.6%	0.999
Mean paired-end function	6.202	3.331	100.6%	0.986
Mean kernel function	6.251	3.356	101.4%	0.986

Note: Ratio is mean divided by mean of paired-end data and Correlation is the correlation between coverage calculations with the method listed in the row versus those obtained from the paired-end data.

ISSN: 1471-2105