Figure 2

Top 30 enriched terms for DAVID and STOP analysis of Htt interacting proteins and STOP analysis of Parkinson’s genes. Fifty-nine genes from the HPRD database known to interact with the Human Huntingin (HTT) gene were analyzed using STOP and DAVID (GO). 14 proteins known to be involved in Parkinson’s disease were analyzed with STOP. (A) The list of HTT interacting proteins was submitted to DAVID, and enrichment analysis carried out with GO_all using SwissProt Human as the background. The top 30 annotations are shown. (B) The same proteins were also submitted to STOP with the same background, and the results were limited to annotations from the preferred ontologies. (C) The Parkinson’s related proteins were similarly analyzed with STOP; again limited to annotations from the preferred ontologies. The top 30 categories are shown along with their significance. Significance is defined as the -log(Benjamini-Hochberg corrected p-values). For reference, p = 0.01 is equivalent to 2