TY - JOUR AU - Zerck, Alexandra AU - Nordhoff, Eckhard AU - Lehrach, Hans AU - Reinert, Knut PY - 2013 DA - 2013/02/18 TI - Optimal precursor ion selection for LC-MALDI MS/MS JO - BMC Bioinformatics SP - 56 VL - 14 IS - 1 AB - Liquid chromatography mass spectrometry (LC-MS) maps in shotgun proteomics are often too complex to select every detected peptide signal for fragmentation by tandem mass spectrometry (MS/MS). Standard methods for precursor ion selection, commonly based on data dependent acquisition, select highly abundant peptide signals in each spectrum. However, these approaches produce redundant information and are biased towards high-abundance proteins. SN - 1471-2105 UR - https://doi.org/10.1186/1471-2105-14-56 DO - 10.1186/1471-2105-14-56 ID - Zerck2013 ER -