Figure 3

Validation approach: Step 1: Create an original network from a canonical GeneGO Pathway Map. These initial Pathway Interactions begin as active interactions (solid lines). Step 2: Expand the network by adding direct interaction to create new regions of Non-Pathway Interactions considered to be non-active (dotted lines). Step 3: Vary the network to create I^∗ using the 90/10 rule. Notice that interactions in the class {T R} mostly remain active among Pathway Interactions, whereas interactions in the class {+P,Z} mostly remain active among the Non-Pathway Interactions. Step 4: Create simulation data r _k and recover active interactions A _k via the black box (algorithm under evaluation).