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Table 3 Comparison of the proposed method, EDGE and Sohn’s method for the single group test by FPR (proportion of falsely rejected hypotheses over the total number of rejected hypotheses) and sensitivity (proportion of true positives correctly identified)

From: More powerful significant testing for time course gene expression data using functional principal component analysis approaches

    Proposeda Proposedb EDGE Sohn’s
Π0=0.05 FDR = 0.01 FPR 0.0016 0.0127 0.0100 0.0091
   Sensitivity 0.7606 0.6864 0.4742 0.5160
  FDR = 0.05 FPR 0.0180 0.0541 0.0459 0.0514
   Sensitivity 0.8440 0.7858 0.6378 0.6616
Π0=0.2 FDR = 0.01 FPR 0.0003 0.0084 0.0079 0.0078
   Sensitivity 0.7716 0.7851 0.6210 0.6302
  FDR = 0.05 FPR 0.0070 0.0409 0.0363 0.0408
   Sensitivity 0.8644 0.8667 0.7652 0.7641
Π0=0.5 FDR = 0.01 FPR 0.0002 0.0053 0.0041 0.0051
   Sensitivity 0.7731 0.8329 0.7021 0.7031
  FDR = 0.05 FPR 0.0025 0.0251 0.0238 0.0244
   Sensitivity 0.8709 0.9049 0.8285 0.8261
  1. Proposed b uses (7) for computing p-values and Proposed a, EDGE and Sohn’s use (8).