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Table 4 Comparison of the proposed method, EDGE and Sohn’s method for the two group test by FPR (proportion of falsely rejected hypotheses over the total number of rejected hypotheses) and sensitivity (proportion of true positives correctly identified)

From: More powerful significant testing for time course gene expression data using functional principal component analysis approaches

   

Proposeda

Proposedb

EDGE

Sohn’s

Π0=0.05

FDR = 0.01

FPR

0.0071

0.0168

0.0079

0.0055

  

Sensitivity

0.6186

0.5638

0.4858

0.4706

 

FDR = 0.05

FPR

0.0432

0.0624

0.0478

0.0377

  

Sensitivity

0.7048

0.6810

0.5850

0.5756

Π0=0.2

FDR = 0.01

FPR

0.0028

0.0099

0.0076

0.0032

  

Sensitivity

0.6530

0.6566

0.5819

0.5153

 

FDR = 0.05

FPR

0.0276

0.0440

0.0400

0.0200

  

Sensitivity

0.7538

0.7579

0.6888

0.6505

Π0=0.5

FDR = 0.01

FPR

0.0013

0.0062

0.0047

0.0011

  

Sensitivity

0.6701

0.7127

0.6370

0.5364

 

FDR = 0.05

FPR

0.0134

0.0286

0.0238

0.0092

  

Sensitivity

0.7850

0.8089

0.7465

0.6817

  1. Proposedb uses (7) for computing p-values and Proposed a, EDGE and Sohn’s use (8).