Skip to main content

Table 4 Comparison of the proposed method, EDGE and Sohn’s method for the two group test by FPR (proportion of falsely rejected hypotheses over the total number of rejected hypotheses) and sensitivity (proportion of true positives correctly identified)

From: More powerful significant testing for time course gene expression data using functional principal component analysis approaches

    Proposeda Proposedb EDGE Sohn’s
Π0=0.05 FDR = 0.01 FPR 0.0071 0.0168 0.0079 0.0055
   Sensitivity 0.6186 0.5638 0.4858 0.4706
  FDR = 0.05 FPR 0.0432 0.0624 0.0478 0.0377
   Sensitivity 0.7048 0.6810 0.5850 0.5756
Π0=0.2 FDR = 0.01 FPR 0.0028 0.0099 0.0076 0.0032
   Sensitivity 0.6530 0.6566 0.5819 0.5153
  FDR = 0.05 FPR 0.0276 0.0440 0.0400 0.0200
   Sensitivity 0.7538 0.7579 0.6888 0.6505
Π0=0.5 FDR = 0.01 FPR 0.0013 0.0062 0.0047 0.0011
   Sensitivity 0.6701 0.7127 0.6370 0.5364
  FDR = 0.05 FPR 0.0134 0.0286 0.0238 0.0092
   Sensitivity 0.7850 0.8089 0.7465 0.6817
  1. Proposedb uses (7) for computing p-values and Proposed a, EDGE and Sohn’s use (8).