Skip to main content


Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Figure 2 | BMC Bioinformatics

Figure 2

From: FAVR (Filtering and Annotation of Variants that are Rare): methods to facilitate the analysis of rare germline genetic variants from massively parallel sequencing datasets

Figure 2

Number of rare SNVs remaining after different stages of SOLiD and TruSeq sequencing data filtering. Mean (of first cousin pairs) number of rare SNVs remaining: (A) without any further filtering and using the PE Bias Detector Tool only, the Rare and True Filter only, or both tools in five families in which sequencing was performed using the SOLiD chemistry, and (B) without any FAVR filtering or using the Rare and True Filter in five families in which sequencing was carried out using the TruSeq chemistry (see Results and discussion). Data were processed according to Pre-FAVR bioinformatic processing and further FAVR filtering was applied as described in FAVR bioinformatic processing (see Methods).

Back to article page