Table 1 Algorithm power
Sample size | BioTile | TileMap | CHARM | BioTile vs. TileMap | BioTile vs. CHARM |
|---|---|---|---|---|---|
5 | 0.06 | 0.56 | 0.09 | OR = 0.05, p = 4.6 × 10-182 | OR = 0.60, p = 1.2 × 10-03 |
10 | 0.83 | 0.48 | 0.27 | OR = 5.45, p = 5.1 × 10-81 | OR = 14.66, p = 1.1 × 10-196 |
15 | 0.89 | 0.48 | 0.44 | OR = 8.34, p = 1.7 × 10-112 | OR = 9.83, p = 5.9 × 10-132 |
20 | 0.93 | 0.67 | 0.49 | OR = 5.17, p = 7.7 × 10-52 | OR = 11.70, p = 4.2 × 10-133 |
DMR length (# probes) | |||||
5 | 0.82 | 0.25 | 0.15 | OR = 11.39, p = 8.9 × 10-29 | OR = 20.14, p = 7.2 × 10-40 |
10 | 0.91 | 0.60 | 0.24 | OR = 3.64, p = 1.1 × 10-07 | OR = 19.92, p = 2.6 × 10-39 |
15 | 0.93 | 0.72 | 0.39 | OR = 4.86, p = 1.0 × 10-08 | OR = 17.82, p = 2.6 × 10-32 |
20 | 0.97 | 0.78 | 0.62 | OR = 9.25, p = 2.4 × 10-09 | OR = 22.21, p = 2.4 × 10-22 |
25 | 0.95 | 0.83 | 0.69 | OR = 3.65, p = 1.2 × 10-04 | OR = 7.12, p = 3.5 × 10-11 |
30 | 0.99 | 0.84 | 0.77 | OR = 18.65, p = 2.2 × 10-08 | OR = 29.94, p = 2.9 × 10-13 |
Log 2 fold change | |||||
0.1 | 0.74 | 0.36 | 0.35 | OR = 4.93, p = 7.7 × 10-19 | OR = 5.18, p = 7.0 × 10-20 |
0.5 | 0.90 | 0.58 | 0.36 | OR = 7.26, p = 1.1 × 10-14 | OR = 18.17, p = 1.8 × 10-33 |
0.75 | 0.97 | 0.57 | 0.37 | OR = 20.17, p = 1.1 × 10-10 | OR = 41.03, p = 2.4 × 10-18 |
1 | 0.97 | 0.83 | 0.50 | OR = 7.90, p = 5.0 × 10-08 | OR = 43.53, p = 3.5 × 10-41 |
1.5 | 1.00 | 0.85 | 0.63 | OR = 55.96, p = 2.9 × 10-14 | OR = 194.39, p = 1.9 × 10-41 |
2 | 1.00 | 0.88 | 0.75 | OR = Inf, p = 1.4 × 10-03 | OR = Inf, p = 4.0 × 10-07 |