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Table 2 Indices used to evaluate the prediction method

From: An improved sequence based prediction protocol for DNA-binding proteins using SVM and comprehensive feature analysis

Index Definition and formula
Acc (TP + TN)/(TP + TN + FP + FN)
AUC area under the receiving operating characteristic curve
F-score 2 · TP/(2TP + FP + FN)
Sen TP/(TP + FN)
Sp TN/(TN + FP)
MCC TP TN - FN FP TP + FN TP + FP TN + FN TP + FP
  1. TP (true positive); TN (true negative); FP (false positive); FN (false negative);
  2. Acc, overall accuracy; AUC, area under ROC; Sen, sensitivity; Sp, specificity; F-score, 2×precision×sensitivity/(precision+sensitivity); MCC, Matthews’s correlation coefficient.