Figure 3

Type I error rates. Type I error rates, for the six methods providing nominal p-values, in simulation studies B_0^0 (panel A), P_0^0 (panel B), S_0^0 (panel C) and R_0^0 (panel D). Letting some counts follow a Poisson distribution (panel B) reduced the type I error rates for TSPM slightly but had overall a small effect. Including outliers with abnormally high counts (panels C and D) had a detrimental effect on the ability to control the type I error for edgeR and NBPSeq, while DESeq became slightly more conservative.