Figure 3

Type I error rates. Type I error rates, for the six methods providing nominal p-values, in simulation studies $B_0^0$ (panel A), $P_0^0$ (panel B), $S_0^0$ (panel C) and $R_0^0$ (panel D). Letting some counts follow a Poisson distribution (panel B) reduced the type I error rates for TSPM slightly but had overall a small effect. Including outliers with abnormally high counts (panels C and D) had a detrimental effect on the ability to control the type I error for edgeR and NBPSeq, while DESeq became slightly more conservative.