BMC Bioinformatics

Table 5 Estimated networks for the SCA1 and SCA3 phenotypes

From: An inferential framework for biological network hypothesis tests

SCA1
PCNA	1.0	.	.	.	0.60	0.65	.	−0.75	.	−0.59	−0.59	.	.
TOP2A		1.0	−0.64	.	.	.	0.53	.	.	.	.	0.52	−0.48
MCM3			1.0	−0.43	.	−0.41	.	.	0.66	.	.	0.88	−0.72
MCM6				1.0	.	.	−0.72	.	0.64	.	.	0.49	−0.44
MCM2					1.0	.	.	.	−0.46	0.55	.	.	.
TK1						1.0	.	0.66	0.47	0.50	.	.	.
CDC6							1.0	0.58	.	.	.	.	.
RFC4								1.0	.	.	−0.77	.	.
CDC45L									1.0	.	.	−0.62	0.80
RFC3										1.0	.	.	.
POLA2											1.0	0.61	−0.43
CDC7												1.0	0.77
RRM2													1.0
SCA3
PCNA	1.0	−0.52	.	.	0.37	0.42	0.64	.	0.34	.	.	0.34	−0.44
TOP2A		1.0	0.36	−0.49	0.37	.	0.84	.	0.62	0.35	.	.	−0.56
MCM3			1.0	.	0.47	.	.	0.47.	−0.40	−0.60	−0.40	.	.
MCM6				1.0	0.60	0.34	.	−0.40	.	0.37	.	−0.43	.
MCM2					1.0	−0.44	−0.43	.	.	.	.	0.45	.
TK1						1.0	−0.35	.	.	.	.	.	.
CDC6							1.0	.	−0.42	.	0.39	.	0.70
RFC4								1.0	0.34	0.82	0.49	−0.46	.
CDC45L									1.0	−0.37	.	.	0.60
RFC3										1.0	−0.58	0.34	.
POLA2											1.0	0.46	.
CDC7												1.0	.
RRM2													1.0

The estimated SCA1 and SCA3 Gaussian graphical model networks for the DNA synthesis and replication genes. Off-diagonal non-zero weights indicate the presence of an edge between two genes, ‘.’ denotes the lack of an edge, and ‘1.0’ is a visual placeholder.

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