Using context-specific effect of miRNAs to identify functional associations between miRNAs and gene signatures

BMC Bioinformatics

Table 2 Rank of enriched miRNAs in gene lists downregulated and differentially expressed genes after miRNA treatment

	PPI-based regression model	Regression model	Expression2Kinase	GeneSet2miRNA
Downregulated gene set in LNCaP cells
pre-miRNA-1	1st	1st	1st	1st
pre-miRNA-206	1st	1st	1st	2nd
pre-miRNA-27b	1st	2nd	1st	1st
pre-miRNA-32	1st	3nd	5st	3st
pre-miRNA-148a	1st	1nd	3st	1st
Differentially expressed gene set in LNCaP
pre-miRNA-1	1^st	2nd	1^st	2nd
pre-miRNA-206	1^st	1^st	1^st	2nd
pre-miRNA-27b	2nd	3rd	10th	15th
Downregulated gene set in HeLa cells
miRNA-1	1^st	1^st	1^st	2nd
miRNA-124	1^st	1^st	2nd	2nd
miRNA-373	1st	1^st	2nd	2nd

ISSN: 1471-2105