Figure 6

An example of functional orthologs predicted by subnetwork alignment. A subnetwork alignment between E. coli (proteins labeled in blue) and P. falciparum (proteins labeled in red). Because the subnetworks are similar and composed almost entirely of proteins with low BLAST E-values, that is, homologous pairs, it is likely that Q8IAN4 and P11557 are functional homologs, despite their low sequence similarity.