Table 1 Representative P. falciparum proteins that were predicted to be involved in cell cycle regulatory network.
Functional category | PlasmoDB accession number | Annotation |
|---|---|---|
Cyclin | PFL1330c | Cyclin-related protein, Pfcyc-2 |
Cell differentiation | PFE0375w | cell differentiation protein, putative (CAF40) |
Chromosome organization | PFE0450w | Chromosome condensation protein, putative |
| Â | PF11_0062 | Histone H2B |
Mitosis | PF13_0050 | HORMA domain protein, putative |
DNA repair | MAL7P1.145 | Mismatch repair protein pms1 homologue, putative; |
| Â | PF10_0114 | DNA repair protein RAD23, putative |
| Â | PF08_0126 | DNA repair protein rad54, putative |
DNA replication | PF07_0023 | DNA replication licensing factor mcm7 homologue, putative |
| Â | PFL0580w | DNA replication licensing factor MCM5, putative |
| Â | MAL7P1.21 | Origin recognition complex subunit 2, putative |
| Â | PFE1345c | Minichromosome maintenance protein 3, putative |
Regulation of cell cycle | PF07_0047 | AAA family ATPase, CDC48 subfamily (Cdc48) |
| Â | PFL1925w | Cell division protein FtsH, putative |
Protein phosphorylation | PFC0105w | Serine/threonine protein kinase, putative |
| Â | MAL13P1.278 | Serine/threonine protein kinase, putative |
| Â | PF14_0294 | Mitogen-activated protein kinase 1 |
| Â | PFC0755c | Protein kinase, putative |
| Â | PF11_0464 | Ser/Thr protein kinase, putative |
| Â | PF11_0156 | Ser/Thr protein kinase |
| Â | PF11_0239 | Calcium-dependent protein kinase, putative |
| Â | PFL1370w | NIMA-related protein kinase, Pfnek-1 |
Proteolysis | PF14_0517 | Peptidase, putative |
| Â | MAL13P1.184 | Endopeptidase, putative |
| Â | PFL1635w | Ulp1 protease, putative |
| Â | PF10_0150 | Methionine aminopeptidase |
Cytoskeleton | MAL8P1.146 | filament assembling protein, putative |
Heat shock | PFI0875w | Heat shock protein 70 (HSP70) homologue |
| Â | PFL0565w | Heat shock protein DNAJ homologue Pfj4 |
| Â | PF11_0351 | Heat shock protein hsp70 homologue |
| Â | PF11_0188 | Heat shock protein 90, putative |
| Â | PF07_0029 | Heat shock protein 86 |
| Â | PF08_0054 | Heat shock 70 kDa protein |
| Â | PFB0595w | Heat shock 40 kDa protein, putative |
| Â | PFI0355c | ATP-dependent heat shock protein, putative |
Pathogenesis | PFC0005w | Erythrocyte membrane protein 1, PfEMP1 |
| Â | PFI0005w | Erythrocyte membrane protein 1, PfEMP1 |
| Â | PFD0005w | Erythrocyte membrane protein 1, PfEMP1 |
| Â | PF08_0103 | Erythrocyte membrane protein 1, PfEMP1 |
| Â | PFL0935c | Erythrocyte membrane protein 1, PfEMP1 |
| Â | PFL0005w | Erythrocyte membrane protein 1, PfEMP1 |
| Â | PFB1055c | Erythrocyte membrane protein 1, PfEMP1 |
| Â | PFI1830c | Erythrocyte membrane protein 1, PfEMP1 |
Microtubule cytoskeleton organization and activity | PFC0165w | Spindle pole body protein, putative |
| Â | PF07_0104 | Kinesin-like protein, putative |
Transcriptional regulation | PF10_0143 | Transcriptional coactivator ADA2 (ADA2) |
| Â | PFD0985w | AP2/ERF domain-containing protein PFD0985w |
| Â | PFL1085w | Transcription factor with AP2 domain, putative |
| Â | PF11_0442 | Transcription factor with AP2 domain, putative |
| Â | PFE0840c | Transcription factor with AP2 domain, putative |
| Â | PF07_0126 | Transcription factor with AP2 domain, putative |
| Â | PF10_0075 | Transcription factor with AP2 domain, putative |
| Â | PFL1900w | Transcription factor with AP2 domain, putative |
| Â | PFL0465c | Zinc finger transcription factor (Krox1) |