Table 1 The degree of pathway perturbation as related to the exposure concentration of naphthenic acids (NAs).
KEGG pathway name (entry) | low | mid | high | Involved genes (total number) |
|---|---|---|---|---|
Ribosome (eco03010) | 0.32 | 0.40 | 0.45 | rplN, rplY, rpmB, rpsB, rpsJ, rpsL, rpsM, rpsO, rpsP, rpsT, rpsU, rrnA, rrnB, rrnC, rrnD, rrnH (16) |
Metabolic pathways (eco01100) | 0.45 | 0.42 | 0.69 | aceB, acnB, aspA, gatY, ilvC, lpxC, manX, ribB, rpiA, serC (10) |
Microbial metabolism in diverse environments (eco01120) | 0.59 | 0.45 | 0.78 | aceB, acnB, manX, rpiA, serC (5) |
Biosynthesis of amino acids (eco01230) | 0.55 | 0.38 | 0.95 | acnB, ilvC, rpiA, serC (4) |
Biosynthesis of secondary metabolites (eco01110) | 0.55 | 0.63 | 0.95 | acnB, ilvC, rpiA, yfbE (4) |
Amino sugar and nucleotide sugar metabolism (eco00520) | 0.61 | 0.52 | 0.79 | manX, ptsG, yfbE (3) |
2-Oxocarboxylic acid metabolism (eco01210) | 0.10 | 0.25 | 1.00 | acnB, ilvC (2) |
Aminoacyl-tRNA biosynthesis (eco00970) | 0.71 | 0.67 | 1.00 | ileX, tyrS (2) |
Glycerophospholipid metabolism (eco00564) | 0.39 | 0.37 | 0.76 | glpA, glpD (2) |
Glyoxylate and dicarboxylate metabolism (eco00630) | 0.30 | 0.49 | 0.79 | aceB, acnB (2) |
Nitrogen metabolism (eco00910) | 0.68 | 0.73 | 0.80 | aspA, yadF (2) |
Phosphotransferase system (PTS) (eco02060) | 0.41 | 0.37 | 0.62 | ptsG, treB (2) |
ABC transporters (eco02010) | 0.48 | 0.50 | 0.67 | oppA (1) |
Citrate cycle (TCA cycle) (eco00020) | 0.20 | 0.50 | 1.00 | acnB (1) |
Fructose and mannose metabolism (eco00051) | 0.33 | 0.24 | 0.52 | manX (1) |
Glycolysis/Gluconeogenesis (eco00010) | 0.50 | 0.33 | 0.83 | ptsG (1) |
Lipopolysaccharide biosynthesis (eco00540) | 0.17 | 0.38 | 0.73 | lpxC (1) |
Oxidative phosphorylation (eco00190) | 0.00 | 0.00 | 1.00 | ppa (1) |
Pantothenate and CoA biosynthesis (eco00770) | 0.00 | 0.00 | 1.00 | ilvC (1) |
Propanoate metabolism (eco00640) | 0.20 | 0.50 | 1.00 | acnB (1) |
Pyruvate metabolism (eco00620) | 0.41 | 0.49 | 0.59 | aceB (1) |
Valine, leucine and isoleucine biosynthesis (eco00290) | 0.00 | 0.00 | 1.00 | ilvC (1) |