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Table 1 Microarray vs. RNA-seq

From: Towards the integration, annotation and association of historical microarray experiments with RNA-seq

  Microarray RNA-seq
Principle Hybridization Cloning & sequencing
Required amount of RNA High Low
Resolution Several to 100 bp Single base
Distinguish Allelic expression? Limited Yes
Distinguish splice forms? Limited Yes
Discover new genes? No Yes
Strandedness? No Yes
Dynamic range Few hundred-fold > 8000-fold
Reproducibility Yes Yes
Cost Medium High (due to computation)