Figure 2

Mapping of human genome onto mouse chromosome using synteny computed a) from BLAST hits and b) from SyC. A synteny image of the mouse genome, as compared to human genome using a) BLAST scores and dotplots in the original human sequencing paper [33] (reproduced with permission from Nature Publishing Group) and b) using NC and SyC scores between human and mouse from GenFamClust. a) has been computed by using synteny information from the dot plot for whole genomic matching regions of 300 kbp size or more, while b) has been computed by determining gene teams of at least size 5 and with a minimum NC and SyC of 0.5. Each chromosome in b) has been normalized by the size of chromosome for comparison with a). White lines represent lack of synteny in a) and b), while black lines (only in b)) represent break in synteny in neighboring gene within the same chromosome. Counting all breaks in syntenic regions (white lines, black lines and change of chromosome), there are 294 syntenic segments with 208 regions (change of chromosome only) for b) as compared to 342 syntenic segments with 217 blocks of consistent color.