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Table 1 Interactions between three NA inhibitors and the H7N9 NA binding site residues

From: Structural analysis of the novel influenza A (H7N9) viral Neuraminidase interactions with current approved neuraminidase inhibitors Oseltamivir, Zanamivir, and Peramivir in the presence of mutation R289K

NA Inhibitor Non-mutated NA R289K-mutated NA #H-bond*
Oseltamivir Arg367, Glu422 Arg367, Glu422 2/2
Zanamivir Arg152, Glu422 Glu422, Lys289 4/3
Peramivir Glu274 Glu422 3/2
  1. *numbers of hydrogen bond between the inhibitor and NA: before/after mutation occurs
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BMC Bioinformatics

ISSN: 1471-2105

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