Table 8 Additional conserved complexes found in human
From: Identifying conserved protein complexes between species by constructing interolog networks
ID | Complex name | Size | Jaccard score | Functional category | Function description |
|---|---|---|---|---|---|
4392 | EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3C) | 5 | 0.57 | Translation | Translation initiation |
4403 | EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3J) | 5 | 0.57 | Translation | Translation initiation |
104 | RNA polymerase II core complex | 12 | 0.69 | Transcription | mRNA synthesis |
2685 | RNA polymerase II | 17 | 0.59 | Transcription | mRNA synthesis |
2686 | BRCA1-core RNA polymerase II complex | 13 | 0.64 | Transcription | mRNA synthesis |
471 | PCAF complex | 10 | 0.6 | Transcription, DNA processing | DNA conformation modification (e.g. chromatin), modification by acetylation, deacetylation, organization of chromosome structure. |
2200 | RFC2-5 subcomplex | 4 | 0.5 | DNA processing | DNA synthesis and replication |
387 | MCM complex | 6 | 0.6 | DNA processing | Chromosome maintainance, DNA synthesis and replication |
369 | MMR complex 2 | 4 | 0.67 | DNA processing | DNA damage repair |
290 | MSH2-MLH1-PMS2-PCNA DNA-repair initiation complex | 4 | 0.67 | DNA processing | DNA damage repair initiation |
1169 | SNARE complex | 4 | 0.6 | Cellular transport, vesicular transport | Vesicle fusion, synaptic vesicle exocytosis |
562 | LSm2-8 complex | 7 | 0.67 | RNA processing | mRNA splicing |
561 | LSm1-7 complex | 7 | 0.67 | RNA processing | Control of mRNA stability during splicing |
3036 | Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) | 5 | 0.5 | Cell cycle, protein fate | Mitotic cell cycle and cell cycle control, modification by ubiquitination, deubiquitination |
2188 | Ubiquitin E3 ligase (CDC34, NEDD8, BTRC, CUL1, SKP1A, RBX1) | 5 | 0.5 | Cell cycle, protein fate | Mitotic cell cycle and cell cycle control, modification by ubiquitination, deubiquitination |
2189 | Ubiquitin E3 ligase (SMAD3, BTRC, CUL1, SKP1A, RBX1) | 5 | 0.5 | Cell cycle, protein fate | Mitotic cell cycle and cell cycle control, modification by ubiquitination, deubiquitination |