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Table 8 Additional conserved complexes found in human

From: Identifying conserved protein complexes between species by constructing interolog networks

ID Complex name Size Jaccard score Functional category Function description
4392 EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3C) 5 0.57 Translation Translation initiation
4403 EIF3 complex (EIF3A, EIF3B, EIF3G, EIF3I, EIF3J) 5 0.57 Translation Translation initiation
104 RNA polymerase II core complex 12 0.69 Transcription mRNA synthesis
2685 RNA polymerase II 17 0.59 Transcription mRNA synthesis
2686 BRCA1-core RNA polymerase II complex 13 0.64 Transcription mRNA synthesis
471 PCAF complex 10 0.6 Transcription, DNA processing DNA conformation modification (e.g. chromatin), modification by acetylation, deacetylation, organization of chromosome structure.
2200 RFC2-5 subcomplex 4 0.5 DNA processing DNA synthesis and replication
387 MCM complex 6 0.6 DNA processing Chromosome maintainance, DNA synthesis and replication
369 MMR complex 2 4 0.67 DNA processing DNA damage repair
290 MSH2-MLH1-PMS2-PCNA DNA-repair initiation complex 4 0.67 DNA processing DNA damage repair initiation
1169 SNARE complex 4 0.6 Cellular transport, vesicular transport Vesicle fusion, synaptic vesicle exocytosis
562 LSm2-8 complex 7 0.67 RNA processing mRNA splicing
561 LSm1-7 complex 7 0.67 RNA processing Control of mRNA stability during splicing
3036 Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) 5 0.5 Cell cycle, protein fate Mitotic cell cycle and cell cycle control, modification by ubiquitination, deubiquitination
2188 Ubiquitin E3 ligase (CDC34, NEDD8, BTRC, CUL1, SKP1A, RBX1) 5 0.5 Cell cycle, protein fate Mitotic cell cycle and cell cycle control, modification by ubiquitination, deubiquitination
2189 Ubiquitin E3 ligase (SMAD3, BTRC, CUL1, SKP1A, RBX1) 5 0.5 Cell cycle, protein fate Mitotic cell cycle and cell cycle control, modification by ubiquitination, deubiquitination