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Figure 3 | BMC Bioinformatics

Figure 3

From: Agent based modeling of Treg-Teff cross regulation in relapsing-remitting multiple sclerosis

Figure 3

Entity behaviors vs time in hill patients. Simulation of eight randomly-selected hill virtual patients. We suppose that the breakdown of the cross regulation mechanism is due to a lower duplication rate p t of Treg. Simulation time is 5 years (18250 time-steps). Red lines represent activated Teff behaviors, blue lines represent activated Treg behaviors and green lines viruses behaviors. In this case the number of Teff peaks is higher. Moreover each peak reaches higher values in respect to healthy patients, thus indicating that higher numbers of self-reactive Teff may entitle higher probabilities of having unrecoverable damage.

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