Figure 10

Analysis of CCLE experimental data in context of apoptosis. (a) Different paths between the nodes TRAIL and DEF40 are highlighted in the Apoptosis pathway map. The orange Bubble Set shows the chosen path. (b) The selected path is shown in context of associated mRNA expression, copy number, and mutation status data from the CCLE dataset with about 350 samples each. As indicated by the arrows, highlighting all samples with an increased copy number of TNFSF10 reveals the correlation with increased expression levels in the ovary cell lines. Notice that while the labels shown in the enRoute view are not identical to the labels in the pathway view, the labels are homologous and deviate since pathway databases use one of many aliases for genes or proteins.