A demonstration of a cavity formed by Val119, Val150, Thr152 and Arg208. Top: In the temporal scatterplot we see that this cavity is frequently present over the entire temporal domain. Middle: The chemical properties are very stable as well, where the dominant ones are hydrophobicity and polarity. We can also note a small positively charged cavity characteristic. Bottom: A close-up on the cavity in five consecutive time steps (465,46,467,468 and 469). We can also observe the actual chemical properties directly in the vicinity of the cavity surface.