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Table 4 Illustration of the key steps in the proposed method

From: Protein disulfide topology determination through the fusion of mass spectrometric analysis and sequence-based prediction using Dempster-Shafer theory

Correct S-S topology: C134-176, C247-C266
Initial Connectivity {pairs(bond, belief)}
MS/MS SVM CSP
(134-176, 0.80) (134-247, 0.96) (134-176, 021)
(247-266, 0.81)   (247-266, 0.21)
Primitive hypothesis
{(134-176), (247-266), (134-247)}
Power Set
{(134-176), (247-266), (134-247), {(134-176),(247-266)}}
Power set scoring (per method)
MS/MS SVM CSP
(134-176, 0.34) (134-176, 0.00) (134-176, 0.20)
(247-266, 0.33) (247-266, 0.00) (247-266, 0.20)
(134-247, 0.00) (134-247, 1.00) (134-247, 0.00)
{(134-176,247-266), 0.33} {(134-176,247-266), 0.00} {(134-176,247-266), 0.20}
Global S-S connectivity (per combination rule)
Dempster rule Campos rule Shafer rule
(134-176, 0.47) (134-176, 0.15) (134-176, 0.35)
(247-266, 0.47) (247-266, 0.15) (247-266, 0.36)
*Yager rule: no S-S bonds were found (belief assignments were lower than 0.01)