Table 1 Total binding energies of the 19 epitope candidates (in descending HLA-B*4405 binding energy ranks).
Position | Sequence | Docked to HLA-B*4405 Docked to DM1-TCR | |||
|---|---|---|---|---|---|
Energy | Rank | Energy | Rank | ||
240 | QEGRMNYYW | -1,006 | 1 | -541.7 | 17 |
188 | KEVLVLWGI | -921.8 | 2 | -573.9 | 13 |
128 | FERFEIFPK | -869.9 | 3 | -594.6 | 12 |
482 | FEFYHKCDN | -846.8 | 4 | -743.9 | 2 |
259 | FEATGNLVV | -815.2 | 5 | -608.9 | 10 |
400 | IEKMNTQFT | -775.8 | 6 | -688.5 | 5 |
131 | FEIFPKTSS | -752.9 | 7 | -560.5 | 14 |
251 | VEPGDKITF | -743.3 | 8 | -599.1 | 11 |
229 | PEIAIRPKV | -687.7 | 9 | -548.9 | 15 |
50 | LEDKHNGKL | -661.4 | 10 | -552.1 | 16 |
274 | MERNAGSGI | -644 | 11 | - | - |
514 | REEIDGVKL | -643.8 | 12 | -666.3 | 7 |
81 | PECESLSTA | -633.3 | 13 | - | - |
446 | LENERTLDY | -603.1 | 14 | -621.1 | 9 |
412 | KEFNHLEKR | -599.5 | 15 | -737.2 | 3 |
493 | MESVKNGTY | -543 | 16 | -645 | 8 |
475 | KEIGNGCFE | -519.6 | 17 | -715.4 | 4 |
463 | YEKVRSQLK | -475.3 | 18 | -751.3 | 1 |
421 | IENLNKKVD | -464.6 | 19 | -666.7 | 6 |