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Table 3 Seven 2009-H1N1 T cell epitope candidates that could be cross-reactive with 2004-H5N1 T cell responses.

From: Molecular docking analysis of 2009-H1N1 and 2004-H5N1 influenza virus HLA-B*4405-restricted HA epitope candidates: implications for TCR cross-recognition and vaccine development

2009_H1N1
position
Strain Sequence MHC-bound predicted score Docked to HLA-B*4405 Docked to DM1-TCR
Energy Energy
50 2009-H1N1 LED K HNGKL 1.0508 -661.4 -552.1
  2004-H5N1 LEKT HNGKL 1.1478 -715.0 -682.2
412 2009-H1N1 K EFNH LEKR 0.9764 -599.5 -737.2
  2004-H5N1 R EFNN LEKR 0.9949 -638.9 -640.8
446 2009-H1N1 L ENE RTLD Y 1.1929 -603.1 -621.1
  2004-H5N1 M E NER TLDF 1.5813 -563.5 -667.2
493 2009-H1N1 M ESVK NGTY 1.73 -543.0 -645.0
  2004-H5N1 MES VR N GTY 1.6645 -595.0 -667.5
421 2009-H1N1 IENLNKK V D 0.8563 -464.6 -666.0
  2004-H5N1 IENLNKKME 0.7968 -466.1 -642.0
475 2009-H1N1 KE I GNGCFE 0.9892 -519.6 -715.4
  2004-H5N1 K EL GNGCFE 0.8258 -548.9 -733.8
482 2009-H1N1 FEFYHK CDN 1.1128 -846.8 -743.9
  2004-H5N1 FEFYHK CDN 1.1129 -846.8 -743.9
  1. *Different residues are underlined. The residues that interacted with DM1-TCR are highlighted in bold.
  2. Two significant changes in TCR binding energy are marked in bold.