iStable: off-the-shelf predictor integration for predicting protein stability changes

BMC Bioinformatics

Table 11 Evaluation of iStable prediction results with data from pH-temperature ranges by accuracy

pH	< = 6			6~8			> 8
Temperature	< = 37	37~65	> 65	< = 37	37~65	> 65	< = 37	37~65	> 65
I-Mutant_PDB	0.38	0.68	0.55	0.22	0.42	0.73	0.18	0.69	0.08
I-Mutant_SEQ	0.46	0.79	0.77	0.25	0.62	0.73	0.18	0.46	0.42
AUTO-MUTE_SVM	0.38	0.81	0.97	0.20	0.43	0.79	0.09	0.69	0.33
AUTO-MUTE_RF	0.48	0.97	1.00	0.28	0.47	0.85	0.09	0.77	0.83
MUPRO	0.46	0.69	0.90	0.40	0.49	0.88	0.27	0.85	0.58
PoPMuSiC	0.13	0.17	0.35	0.29	0.36	0.60	0.09	0.38	0.17
CUPSAT	0.57	0.59	0.55	0.38	0.59	0.54	0.27	0.54	0.50
iStable	0.61	0.94	1.00	0.55	0.77	0.88	0.27	0.77	0.75

ISSN: 1471-2105