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Table 8 Comparison of performance based on secondary structure

From: iStable: off-the-shelf predictor integration for predicting protein stability changes

Secondary Structure Predictors Sn Sp Acc MCC
Helix      
  iStable 0.702 0.933 0.850 0.666
  I-Mutant_PDB 0.415 0.901 0.728 0.371
  I-Mutant_SEQ 0.520 0.929 0.784 0.509
  AUTO-MUTE_RF 0.563 0.987 0.834 0.647
  AUTO-MUTE_SVM 0.495 0.957 0.792 0.536
  MUPRO_SVM 0.639 0.915 0.818 0.591
  PoPMuSiC2.0 0.250 0.957 0.708 0.311
  CUPSAT 0.541 0.778 0.693 0.323
Sheet      
  iStable 0.691 0.946 0.876 0.676
  I-Mutant_PDB 0.348 0.944 0.782 0.385
  I-Mutant_SEQ 0.495 0.948 0.825 0.520
  AUTO-MUTE_RF 0.455 0.984 0.838 0.567
  AUTO-MUTE_SVM 0.297 0.996 0.805 0.426
  MUPRO_SVM 0.417 0.904 0.770 0.370
  PoPMuSiC2.0 0.310 0.956 0.776 0.363
  CUPSAT 0.417 0.796 0.697 0.213
Other      
  iStable 0.680 0.943 0.847 0.666
  I-Mutant_PDB 0.365 0.893 0.699 0.311
  I-Mutant_SEQ 0.358 0.924 0.716 0.354
  AUTO-MUTE_RF 0.479 0.995 0.805 0.595
  AUTO-MUTE_SVM 0.386 0.954 0.745 0.434
  MUPRO_SVM 0.485 0.900 0.748 0.433
  PoPMuSiC2.0 0.330 0.889 0.688 0.270
  CUPSAT 0.474 0.766 0.662 0.249
  1. Helix: α helix; Sheet: β sheet; Other: turns and coil.